My favourite software to acquire images is Audela. It is not a well-known software but is well worth a try. Its main advantage is that it is completerly customizable and you can even change the interface completely to create your own. It is open-source and free.
It supports many cameras, webcams, DSLRs and telescopes. The interface is in several languages and if need be you can ask questions on Audela's website forums. Here is a screenshot:
After many trials and errors I was finally able to apply autoguiding successfully. Here are my main recommandations if you want to try autoguiding. First of all, you should have a mount capable of supporting 2 telescopes in parallel. In my setup, one telescope is fitted with a Toucam Webcam modified for long exposures and the other telescope has a Canon DSLR. The total weight of this equipment must not be too much for your mount. For instance, with my Vixen GP-DX mount, the total weight of my equipment is about 9 kg : that's still OK for astrophotography but I think it's the maximum.
You must connect the guide port of your mount to the serial port (also called COM port) of the PC. Then you establish the connection between the guiding software and your mount.
Here are a few practical tips:
The software I use most often to process my images is Iris. It is a very effective freeware and Christian Buil's website (the author of the software) is very informative when it comes to understand how to use the program. For instance, I find this webpage very useful because it explains the processing workflow in details.
To process my images, I generally follow the webpage I just mentioned and export the final image as a TIF or BMP image that I open in Photoshop or the Gimp. There I apply various processing such as noise removal, layer combination, sharpening, etc. to get the final result.
I will detail all these steps later.